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Article

Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.

Molecular cancer therapeutics - 1 Nov 2015

Hu Shanhu, Lu Yun, Orr Bernardo, Godek Kristina, Mustachio Lisa Maria, Kawakami Masanori, Sekula David, Compton Duane A, Freemantle Sarah, Dmitrovsky Ethan

Abstract excerpt

Chromosomal instability (CIN) is a hallmark of solid tumor biology and is implicated in carcinogenesis. Preferentially eliminating malignant cells by targeting CIN and aneuploidy is an attractive antineoplastic strategy. We previously reported that CDK2 antagonism causes lung cancer cells to undergo anaphase catastrophe and apoptosis through inhibition of phosphorylation of the centrosomal protein CP110. Cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26304236
DOI: 10.1158/1535-7163.MCT-15-0443
PMCID: PMC4636444

Genes

CDK2
KRAS
USP33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.PMID 26304236Read ↗

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