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Article

Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer

18 Nov 2016

Abstract excerpt

Background: The first generation CDK2/7/9 inhibitor seliciclib (CYC202) causes multipolar anaphase and apoptosis in lung cancer cells with supernumerary centrosomes (known as anaphase catastrophe). We investigated a new and potent CDK2/9 inhibitor, CCT68127 (Cyclacel). Methods: CCT68127 was studied in lung cancer cells (three murine and five human) and control murine pulmonary epithelial and human immortalized...

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PMID: 28376145
DOI: 10.1093/jnci/djw297

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