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Article

Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.

Molecular cancer therapeutics - 1 Nov 2016

Danilov Alexey V, Hu Shanhu, Orr Bernardo, Godek Kristina, Mustachio Lisa Maria, Sekula David, Liu Xi, Kawakami Masanori, Johnson Faye M, Compton Duane A, Freemantle Sarah J, Dmitrovsky Ethan

Abstract excerpt

Despite advances in targeted therapy, lung cancer remains the most common cause of cancer-related mortality in the United States. Chromosomal instability is a prominent feature in lung cancer and, because it rarely occurs in normal cells, it represents a potential therapeutic target. Our prior work discovered that lung cancer cells undergo anaphase catastrophe in response to inhibition of cyclin-dependent kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27550941
DOI: 10.1158/1535-7163.MCT-16-0127
PMCID: PMC5288839

Genes

CDK2
CDK1
KRAS
CDK5
CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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