Article
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
Nature - 1 Jul 2010
D'Angiolella Vincenzo, Donato Valerio, Vijayakumar Sangeetha, Saraf Anita, Florens Laurence, Washburn Michael P, Dynlacht Brian, Pagano Michele
Abstract excerpt
Generally, F-box proteins are the substrate recognition subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes, which mediate the timely proteolysis of important eukaryotic regulatory proteins. Mammalian genomes encode roughly 70 F-box proteins, but only a handful have established functions. The F-box protein family obtained its name from Cyclin F (also called Fbxo1), in which the F-box motif (the...
Topics
- Animals
- Cell Cycle Proteins
- Cell Line
- Cell Line, Tumor
- Centrioles
- Centrosome
- Cyclins
- G2 Phase
- Homeostasis
- Humans
- Mice
- Microtubule-Associated Proteins