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Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1 -Deficient Human and Mouse Small-Cell Lung Cancer

7 Apr 2020

Abstract excerpt

Abstract The RB1 tumor suppressor gene is mutated in highly aggressive tumors including small-cell lung cancer (SCLC), where its loss, along with TP53, is required and sufficient for tumorigenesis. While RB1-mutant cells fail to arrest at G1–S in response to cell-cycle restriction point signals, this information has not led to effective strategies to treat RB1-deficient tumors, as it is challenging to develop...

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PMID: 32265224
DOI: 10.1158/0008-5472.can-19-2400

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