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Article

Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

6 Feb 2018

Abstract excerpt

Significance Despite current treatments, lung cancers remain a major public health problem. Innovative ways are needed to treat or prevent these cancers. Centrosomes are critical for fidelity of mitosis. Abnormal centrosome numbers can cause aberrant mitosis and cell death. Polo-like kinase 4 (PLK4) regulates centriole duplication, and its deregulation alters centrosome number and mitosis. The potent PLK4...

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PMID: 29434041
DOI: 10.1073/pnas.1719760115

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