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Article

Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase.

Science (New York, N.Y.) - 27 May 2016

Fujimitsu Kazuyuki, Grimaldi Margaret, Yamano Hiroyuki

Abstract excerpt

Error-free genome duplication and segregation are ensured through the timely activation of ubiquitylation enzymes. The anaphase-promoting complex or cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, is regulated by phosphorylation. However, the mechanism remains elusive. Using systematic reconstitution and analysis of vertebrate APC/Cs under physiological conditions, we show how cyclin-dependent kinase 1...

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Source

Identifiers

PMID: 27103671
DOI: 10.1126/science.aad3925

Genes

APC
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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