Article

Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification

2024-01-10

Abstract excerpt

Centrosome amplification (CA), an abnormal increase in the number of centrosomes in the cell, is a recurrent phenomenon in lung and other malignancies. Although CA contributes to tumor development and progression by promoting genomic instability (GIN), it also induces mitotic stress that jeopardizes cellular integrity. The presence of extra centrosomes leads to the formation of multipolar mitotic spindles prone to...

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Literature Corpus work: 85cf82dd-e8e9-524f-bab5-fb9bd9b4adda
DOI: 10.1101/2024.01.09.574105

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