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Article

PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.

Cell cycle (Georgetown, Tex.) - 1 Jan 2018

Malaney Prerna, Palumbo Emily, Semidey-Hurtado Jonathan, Hardee Jamaal, Stanford Katherine, Kathiriya Jaymin J, Patel Deepal, Tian Zhi, Allen-Gipson Diane, Davé Vrushank

Abstract excerpt

PTEN phosphorylation at its C-terminal (C-tail) serine/threonine cluster negatively regulates its tumor suppressor function. However, the consequence of such inhibition and its downstream effects in driving lung cancer remain unexplored. Herein, we ascertain the molecular mechanisms by which phosphorylation compromises PTEN function, contributing to lung cancer. Replacement of the serine/threonine residues with...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29108454
DOI: 10.1080/15384101.2017.1388970
PMCID: PMC6103743

Genes

PTEN
MAF1
CDK1
CENPC
EGFR
HDAC1
MCM2
RAD51
RAD52
RPA1
SRF
TRIM28

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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