Article
CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.
Cancer research - 15 May 2015
Hu Shanhu, Danilov Alexey V, Godek Kristina, Orr Bernardo, Tafe Laura J, Rodriguez-Canales Jaime, Behrens Carmen, Mino Barbara, Moran Cesar A, Memoli Vincent A, Mustachio Lisa Maria, Galimberti Fabrizio, Ravi Saranya, DeCastro Andrew, Lu Yun, Sekula David, Andrew Angeline S, Wistuba Ignacio I, Freemantle Sarah, Compton Duane A, Dmitrovsky Ethan
Abstract excerpt
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacologic targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. We previously discovered that CDK2 inhibition causes lung cancer cells with more than two centrosomes to undergo multipolar cell division leading to apoptosis, defined as anaphase...
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