Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.

Molecular biology of the cell - 1 Jun 2012

Hood Emily A, Kettenbach Arminja N, Gerber Scott A, Compton Duane A

Abstract excerpt

Solid tumors are frequently aneuploid, and many display high rates of ongoing chromosome missegregation in a phenomenon called chromosomal instability (CIN). The most common cause of CIN is the persistence of aberrant kinetochore-microtubule (k-MT) attachments, which manifest as lagging chromosomes in anaphase. k-MT attachment errors form during prometaphase due to stochastic interactions between kinetochores and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Segregation
Share to Kinesins
Share to Kinetochores

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mass Spectrometry

Share to Microtubules

Share to Polo-Like Kinase 1

Share to Serine

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 22535524
DOI: 10.1091/mbc.E11-12-1013
PMCID: PMC3374746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.PMID 22535524Read ↗

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.Semantic proximity Read ↗

The CINs of Polo-Like Kinase 1 in CancerSemantic proximity Read ↗

CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1Semantic proximity Read ↗

The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.Semantic proximity Read ↗

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis.Semantic proximity Read ↗

CIP2A coordinates phosphosignaling, mitosis, and the DNA damage responseSemantic proximity Read ↗

TOPBP1-PLK1 interaction preserves genome integrity during mitosis.Semantic proximity Read ↗

A Phosphorylation Switch Governs KIF11’s Mechanical Output During MitosisSemantic proximity Read ↗

KIFC1 in cancer: Understanding its expression, regulation, and therapeutic potentialSemantic proximity Read ↗

MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1.Semantic proximity Read ↗

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.Semantic proximity Read ↗

Bioinformatics Analysis of Kinesin Family Member 2C in Human Tumors: Novel Prognostic Biomarker and Tumor Microenvironment RegulatorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.