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CK2α phosphorylates CHIP for oncogenesis: A novel post-translational switch in cancer

2025-10-15

Abstract excerpt

<h4>ABSTRACT</h4> The post-translational regulation of tumor suppressors by oncogenic kinases remains a critical yet underexplored determinant of proteostasis reprogramming in cancer. Here, we identified the E3 ubiquitin ligase CHIP (C-terminus of Hsc70-Interacting Protein) as a direct and functionally relevant substrate of the serine/threonine kinase CK2α, which is frequently overexpressed in solid tumors. Using...

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Identifiers and source

Literature Corpus work
7c187c37-3011-5902-a3d9-c7cc729f98c1
DOI
10.1101/2025.10.15.682604
Open publication

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CK2α phosphorylates CHIP for oncogenesis: A novel post-translational switch in cancerDOI 10.1101/2025.10.15.682604
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