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Article

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.

Nature genetics - 1 Oct 2015

Janiszewska Michalina, Liu Lin, Almendro Vanessa, Kuang Yanan, Paweletz Cloud, Sakr Rita A, Weigelt Britta, Hanker Ariella B, Chandarlapaty Sarat, King Tari A, Reis-Filho Jorge S, Arteaga Carlos L, Park So Yeon, Michor Franziska, Polyak Kornelia

Abstract excerpt

Detection of minor, genetically distinct subpopulations within tumors is a key challenge in cancer genomics. Here we report STAR-FISH (specific-to-allele PCR-FISH), a novel method for the combined detection of single-nucleotide and copy number alterations in single cells in intact archived tissues. Using this method, we assessed the clinical impact of changes in the frequency and topology of PIK3CA mutation and...

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Identifiers

PMID: 26301495
DOI: 10.1038/ng.3391
PMCID: PMC4589505

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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