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Luminal breast epithelial cells from wildtype and <i>BRCA</i> mutation carriers harbor copy number alterations commonly associated with breast cancer

2024-05-03

Abstract excerpt

Cancer-associated mutations have been documented in normal tissues, but the prevalence and nature of somatic copy number alterations and their role in tumor initiation and evolution is not well understood. Here, using single cell DNA sequencing, we describe the landscape of CNAs in >42,000 breast epithelial cells from women with normal or high risk of developing breast cancer. Accumulation of individual cells with...

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Literature Corpus work
3e59e437-0f73-5963-b66b-288d1c674437
DOI
10.1101/2024.05.01.591587
Open publication

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Luminal breast epithelial cells from wildtype and <i>BRCA</i> mutation carriers harbor copy number alterations commonly associated with breast cancerDOI 10.1101/2024.05.01.591587
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