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Article

A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data.

Genome biology - 25 Sept 2014

Li Bo, Li Jun Z

Abstract excerpt

Intra-tumor heterogeneity reflects cancer genome evolution and provides key information for diagnosis and treatment. When bulk tumor tissues are profiled for somatic copy number alterations (sCNA) and point mutations, it may be difficult to estimate their cellular fractions when a mutation falls within a sCNA. We present the Clonal Heterogeneity Analysis Tool, which estimates cellular fractions for both sCNAs and...

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Identifiers

PMID: 25253082
DOI: 10.1186/s13059-014-0473-4
PMCID: PMC4203890

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