Article
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing.
Genome biology - 9 Dec 2016
Demeulemeester Jonas, Kumar Parveen, Møller Elen K, Nord Silje, Wedge David C, Peterson April, Mathiesen Randi R, Fjelldal Renathe, Zamani Esteki Masoud, Theunis Koen, Fernandez Gallardo Elia, Grundstad A Jason, Borgen Elin, Baumbusch Lars O, Børresen-Dale Anne-Lise, White Kevin P, Kristensen Vessela N, Van Loo Peter, Voet Thierry, Naume Bjørn
Abstract excerpt
BACKGROUND: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.