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Article

IL-22 affects smooth muscle cell phenotype and plaque formation in apolipoprotein E knockout mice.

Atherosclerosis - 1 Oct 2015

Rattik Sara, Hultman Karin, Rauch Uwe, Söderberg Ingrid, Sundius Lena, Ljungcrantz Irena, Hultgårdh-Nilsson Anna, Wigren Maria, Björkbacka Harry, Fredrikson Gunilla Nordin, Nilsson Jan

Abstract excerpt

OBJECTIVE: IL-22 is a recently discovered cytokine that belongs to the family of IL-10 related cytokines. It is produced by activated T-cells and innate lymphoid cells and has been suggested to be involved in tissue repair. As both inflammation and repair play important roles in atherosclerosis we investigated if IL-22 deficiency influences the disease process in Apoe(-/-) mice. METHODS: We generated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26298743
DOI: 10.1016/j.atherosclerosis.2015.08.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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