Article

Macrophage-expressed Neuropilin 2 promotes plaque formation in ApoE knockout mice and is essential for pro-inflammatory macrophage polarisation and gene expression

2023-09-27

Abstract excerpt

<h4>Aims</h4> Atherosclerosis is a chronic inflammatory disease causing the narrowing of arteries, leading to ischaemic heart disease. It is characterised by the subendothelial retention, and modification, of lipoproteins by macrophages, highly plastic cells which undergo polarisation to a pro-inflammatory phenotype in response to cytokines and other environmental stimuli. Neuropilin-2 (NRP2) is a cell-surface co...

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Literature Corpus work: 80e30dc4-6ad8-5389-a0a3-5e4bac169a65
DOI: 10.1101/2023.09.27.558806

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