Article
Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice.
PloS one - 1 Jan 2016
Tsaousi Aikaterini, Hayes Elaine M, Di Gregoli Karina, Bond Andrew R, Bevan Laura, Thomas Anita C, Newby Andrew C
Abstract excerpt
BACKGROUND: Thelper1 (Th1) lymphocytes have been previously implicated in atherosclerotic plaque growth but their role in plaque vulnerability to rupture is less clear. We investigated whether T-bet knockout that prevents Th1 lymphocyte differentiation modulates classical (M1) macrophage activation or production of matrix degrading metalloproteinases (MMPs) and their tissue inhibitors, TIMPs. METHODS & RESULTS:...
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