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Article

EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis.

Circulation - 8 Aug 2017

Finney Alexandra C, Funk Steven D, Green Jonette M, Yurdagul Arif, Rana Mohammad Atif, Pistorius Rebecca, Henry Miriam, Yurochko Andrew, Pattillo Christopher B, Traylor James G, Chen Jin, Woolard Matthew D, Kevil Christopher G, Orr A Wayne

Abstract excerpt

BACKGROUND: Atherosclerotic plaque formation results from chronic inflammation and fibroproliferative remodeling in the vascular wall. We previously demonstrated that both human and mouse atherosclerotic plaques show elevated expression of EphA2, a guidance molecule involved in cell-cell interactions and tumorigenesis. METHODS: Here, we assessed the role of EphA2 in atherosclerosis by deleting EphA2 in a mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hematopoietic Stem Cells

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Identifiers

PMID: 28487392
DOI: 10.1161/CIRCULATIONAHA.116.026644
PMCID: PMC5548618

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