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Article

Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms.

Physiological genomics - 2 Apr 2012

Alexander Matthew R, Murgai Meera, Moehle Christopher W, Owens Gary K

Abstract excerpt

Smooth muscle cell (SMC) phenotypic modulation in atherosclerosis and in response to PDGF in vitro involves repression of differentiation marker genes and increases in SMC proliferation, migration, and matrix synthesis. However, SMCs within atherosclerotic plaques can also express a number of proinflammatory genes, and in cultured SMCs the inflammatory cytokine IL-1β represses SMC marker gene expression and...

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Source

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Identifiers

PMID: 22318995
DOI: 10.1152/physiolgenomics.00160.2011
PMCID: PMC3339851

Genes

CCL20
RGS17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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