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Article

Genetic <i>Ace2</i> Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the <i>ApoE</i> Knockout Mouse

29 Jul 2010

Abstract excerpt

RATIONALE: Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. OBJECTIVE: Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. METHODS AND RESULTS: C57Bl6, Ace2 knockout (KO), apolipoprotein E (ApoE) KO and ApoE/Ace2 double KO mice were followed until 30 weeks of...

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PMID: 20671240
DOI: 10.1161/circresaha.110.219279

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