Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation.

Cardiovascular research - 1 Feb 2014

Sahara Makoto, Ikutomi Masayasu, Morita Toshihiro, Minami Yoshiyasu, Nakajima Toshiaki, Hirata Yasunobu, Nagai Ryozo, Sata Masataka

Abstract excerpt

AIMS: Angiotensin-converting enzyme 2 (ACE2) is known as a negative regulator of the renin-angiotensin system. We aimed to determine the roles of ACE2 on the development of vascular diseases. METHODS AND RESULTS: Using two diversely different models of vascular diseases, hyperlipidaemia-induced atherosclerosis in apolipoprotein E knockout (KO) mice and mechanical injury-induced arterial neointimal hyperplasia in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Angiotensin-Converting Enzyme 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Angiotensin II

Share to Aortic Diseases

Share to Femoral Artery

Share to JNK Mitogen-Activated Protein Kinases

Share to Neointima

Share to Plaque, Atherosclerotic

Source

Identifiers

PMID: 24193738
DOI: 10.1093/cvr/cvt245

Genes

ACE2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation.PMID 24193738Read ↗

Genetic <i>Ace2</i> Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the <i>ApoE</i> Knockout MouseSemantic proximity Read ↗

SARS-CoV-2 induced vascular endothelial dysfunction: direct or indirect effects?Semantic proximity Read ↗

Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice.Semantic proximity Read ↗

Macrophage-derived angiopoietin-like protein 2 accelerates development of abdominal aortic aneurysm.Semantic proximity Read ↗

Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm.Semantic proximity Read ↗

Genetic Ablation of miR-146a Induces Abdominal Aortic Aneurysm Formation by Intensifying Inflammatory M1-Like Macrophages Polarization and Vascular Smooth Muscle Cell Phenotypic Switching.Semantic proximity Read ↗

PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice.Semantic proximity Read ↗

The angiopoietin receptor Tie2 is atheroprotective in arterial endotheliumSemantic proximity Read ↗

Proteinase-Activated Receptor 2 (PAR2) Deficiency and Cardiovascular Regulation: Context-Dependent Effects on Inflammation and FibrosisSemantic proximity Read ↗

Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis-Brief Report.Semantic proximity Read ↗

ACE2 deficiency inhibits thoracic aortic dissection by enhancing SIRT3 mediated inhibition of inflammation and VSCMs phenotypic switch.Semantic proximity Read ↗

Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.