Article
SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis.
Circulation research - 16 Apr 2004
Feil Susanne, Hofmann Franz, Feil Robert
Abstract excerpt
The function of cytoskeletal proteins in the modulation of vascular smooth muscle cell (SMC) phenotype during vascular disease is poorly understood. In this report, we used a combination of gene targeting and Cre/lox-mediated cell fate mapping in mice to investigate the role of SM22alpha, an SMC-specific cytoskeletal protein of unknown function, in the development of atherosclerosis. In hypercholesterolemic...
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