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Article

Effect of MMP-2 deficiency on atherosclerotic lesion formation in apoE-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2006

Kuzuya Masafumi, Nakamura Kae, Sasaki Takeshi, Cheng Xian Wu, Itohara Shigeyoshi, Iguchi Akihisa

Abstract excerpt

OBJECTIVE: Although it has been reported that matrix metalloproteinase (MMP)-2 is a major proteinase in atherosclerotic plaque lesions, there is no direct evidence of the role of MMP-2 in atherosclerotic lesion formation. In the present study we determined the role of MMP-2 in atherosclerosis plaque development using apolipoprotein E-deficient (apoE(-/-)) mice. METHODS AND RESULTS: To generate MMP-2-deficient,...

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PMID: 16556856
DOI: 10.1161/01.ATV.0000218496.60097.e0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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