Article
Overexpression of IL-18 decreases intimal collagen content and promotes a vulnerable plaque phenotype in apolipoprotein-E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2004
de Nooijer R, von der Thüsen J H, Verkleij C J N, Kuiper J, Jukema J W, van der Wall E E, van Berkel J C, Biessen E A L
Abstract excerpt
OBJECTIVE: Although IL-18 has been implicated in atherosclerotic lesion development, little is known about its role in advanced atherosclerotic plaques. This study aims to assess the effect of IL-18 overexpression on the stability of preexisting plaques. METHODS AND RESULTS: Atherosclerotic lesions were elicited in carotid arteries of apolipoprotein E (apoE)-deficient mice (n=32) by placement of a perivascular...
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