Article
Analysis of Polygenic Mutants Suggests a Role for Mediator in Regulating Transcriptional Activation Distance in Saccharomyces cerevisiae.
Genetics - 1 Oct 2015
Reavey Caitlin T, Hickman Mark J, Dobi Krista C, Botstein David, Winston Fred
Abstract excerpt
Studies of natural populations of many organisms have shown that traits are often complex, caused by contributions of mutations in multiple genes. In contrast, genetic studies in the laboratory primarily focus on studying the phenotypes caused by mutations in a single gene. However, the single mutation approach may be limited with respect to the breadth and degree of new phenotypes that can be found. We have...
Topics
- DNA-Binding Proteins
- Gene Expression Regulation, Fungal
- Mediator Complex
- Mutation
- Phenotype
- Regulatory Sequences, Nucleic Acid
- Saccharomyces cerevisiae
- Transcription Initiation Site
- Transcription, Genetic
- Transcriptional Activation