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Article

Defining genetic interaction.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2008

Mani Ramamurthy, St Onge Robert P, Hartman John L, Giaever Guri, Roth Frederick P

Abstract excerpt

Sometimes mutations in two genes produce a phenotype that is surprising in light of each mutation's individual effects. This phenomenon, which defines genetic interaction, can reveal functional relationships between genes and pathways. For example, double mutants with surprisingly slow growth define synergistic interactions that can identify compensatory pathways or protein complexes. Recent studies have used...

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Identifiers

PMID: 18305163
DOI: 10.1073/pnas.0712255105
PMCID: PMC2265146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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