Article
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.
Nature genetics - 1 Sept 2003
Yvert Gaël, Brem Rachel B, Whittle Jacqueline, Akey Joshua M, Foss Eric, Smith Erin N, Mackelprang Rachel, Kruglyak Leonid
Abstract excerpt
Natural genetic variation can cause significant differences in gene expression, but little is known about the polymorphisms that affect gene regulation. We analyzed regulatory variation in a cross between laboratory and wild strains of Saccharomyces cerevisiae. Clustering and linkage analysis defined groups of coregulated genes and the loci involved in their regulation. Most expression differences mapped to...
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