Article
The molecular mechanism of a cis-regulatory adaptation in yeast.
PLoS genetics - 1 Jan 2013
Chang Jessica, Zhou Yiqi, Hu Xiaoli, Lam Lucia, Henry Cameron, Green Erin M, Kita Ryosuke, Kobor Michael S, Fraser Hunter B
Abstract excerpt
Despite recent advances in our ability to detect adaptive evolution involving the cis-regulation of gene expression, our knowledge of the molecular mechanisms underlying these adaptations has lagged far behind. Across all model organisms, the causal mutations have been discovered for only a handful of gene expression adaptations, and even for these, mechanistic details (e.g. the trans-regulatory factors involved)...
Topics
- Adaptation, Physiological
- Antifungal Agents
- Down-Regulation
- Drug Resistance, Fungal
- Ergosterol
- Evolution, Molecular
- Gene Expression Regulation, Fungal
- Membrane Proteins
- Mutation
- Promoter Regions, Genetic