Article
Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross.
eLife - 12 Nov 2020
Renganaath Kaushik, Chong Rockie, Day Laura, Kosuri Sriram, Kruglyak Leonid, Albert Frank W
Abstract excerpt
Sequence variation in regulatory DNA alters gene expression and shapes genetically complex traits. However, the identification of individual, causal regulatory variants is challenging. Here, we used a massively parallel reporter assay to measure the cis-regulatory consequences of 5832 natural DNA variants in the promoters of 2503 genes in the yeast Saccharomyces cerevisiae. We identified 451 causal variants,...
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