Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Mutation of palmitoylation site of linker for activation of T cells inhibits signal transduction mediated by glycosyl phosphatidyl inositol-anchored CD59 in T cells].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Aug 2015

Gao Meihua, Wang Lina, Wang Bing, Cong Beibei, Zhang Shuchao

Abstract excerpt

OBJECTIVE: To construct the lentivirus carrying the mutated palmitoylation site of the linker for activation of T cells (LAT) and infect Jurkat cells with it to establish stable cell line, and to investigate the effect of LAT palmitoylation mutation on T cell signaling induced by CD59. METHODS: Negative control (neg-EGFP) and LAT-M-EGFP fusion protein gene vectors were respectively constructed and then packaged...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD59 Antigens
Share to Glycosylphosphatidylinositols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Jurkat Cells

Share to Lipoylation

Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Share to Membrane Microdomains

Share to Microscopy, Confocal

Share to Phospholipase C gamma

Source

Identifiers

PMID: 26271970

Genes

LAT
LCK
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Mutation of palmitoylation site of linker for activation of T cells inhibits signal transduction mediated by glycosyl phosphatidyl inositol-anchored CD59 in T cells].PMID 26271970Read ↗

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.Semantic proximity Read ↗

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.Semantic proximity Read ↗

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.Semantic proximity Read ↗

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.Semantic proximity Read ↗

The role of prolines and glycine in the transmembrane domain of LAT.Semantic proximity Read ↗

Membrane raft association is a determinant of plasma membrane localization.Semantic proximity Read ↗

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.Semantic proximity Read ↗

Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.Semantic proximity Read ↗

The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.Semantic proximity Read ↗

Activation of STING requires palmitoylation at the Golgi.Semantic proximity Read ↗

A LAT mutation that inhibits T cell development yet induces lymphoproliferation.Semantic proximity Read ↗

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.