Article
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
Immunity - 1 Aug 1998
Zhang W, Trible R P, Samelson L E
Abstract excerpt
The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds Grb2, PLC-gamma1, and other signaling molecules. We demonstrate that human LAT is palmitoylated and that palmitoylated LAT predominantly localizes into glycolipid-enrich...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Substitution
- Carrier Proteins
- Cysteine
- Glycolipids
- Humans
- Jurkat Cells
- Lymphocyte Activation
- Membrane Proteins
- Mutation
- Palmitates
- Phosphoproteins
- Phosphorylation
- Protein Processing, Post-Translational
- Protein Structure, Tertiary
- Protein-Tyrosine Kinases
- Signal Transduction
- T-Lymphocytes