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Article

Activation of STING requires palmitoylation at the Golgi.

Nature communications - 21 Jun 2016

Mukai Kojiro, Konno Hiroyasu, Akiba Tatsuya, Uemura Takefumi, Waguri Satoshi, Kobayashi Toshihide, Barber Glen N, Arai Hiroyuki, Taguchi Tomohiko

Abstract excerpt

Stimulator of interferon genes (STING) is essential for the type I interferon response against DNA pathogens. In response to the presence of DNA and/or cyclic dinucleotides, STING translocates from the endoplasmic reticulum to perinuclear compartments. However, the role of this subcellular translocation remains poorly defined. Here we show that palmitoylation of STING at the Golgi is essential for activation of...

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Identifiers

PMID: 27324217
DOI: 10.1038/ncomms11932
PMCID: PMC4919521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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