Article
Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2011
Balagopalan Lakshmi, Ashwell Benjamin A, Bernot Kelsie M, Akpan Itoro O, Quasba Naeha, Barr Valarie A, Samelson Lawrence E
Abstract excerpt
Linker for activation of T cells (LAT) plays a central role in T-cell activation by nucleating signaling complexes that are critical for the propagation of T-cell signals from the plasma membrane to the cellular interior. The role of phosphorylation and palmitoylation in LAT function has been well studied, but not much is known about other strategies by which the cell modulates LAT activity. We have focused on...
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