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Article

The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2007

Herzog Sebastian, Jumaa Hassan

Abstract excerpt

SLP-65 and the linker for activation of T cells (LAT) are central adaptor proteins that link the activated pre-BCR to downstream events in pre-B cells. Recently, a new transmembrane adaptor called NTAL/LAB/LAT2 (hereafter called NTAL for non-T cell activation linker) with striking functional and structural similarity to LAT has been identified in B cells. In this study, we compare the function of NTAL and LAT in...

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Topics

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17277139
DOI: 10.4049/jimmunol.178.4.2336

Genes

LAT
BCR
LAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.PMID 17277139Read ↗

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.Semantic proximity Read ↗

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.Semantic proximity Read ↗

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.Semantic proximity Read ↗

LAT encodes T cell activation pathway balanceSemantic proximity Read ↗

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.Semantic proximity Read ↗

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read ↗

The adapter proteins LAT and SLP-76 are required for T-cell activation.Semantic proximity Read ↗

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.Semantic proximity Read ↗

Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells.Semantic proximity Read ↗

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.Semantic proximity Read ↗

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