Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A LAT mutation that inhibits T cell development yet induces lymphoproliferation.

Science (New York, N.Y.) - 14 Jun 2002

Sommers Connie L, Park Cheung-Seog, Lee Jan, Feng Chiguang, Fuller Claudette L, Grinberg Alexander, Hildebrand Jay A, Lacaná Emanuela, Menon Rashmi K, Shores Elizabeth W, Samelson Lawrence E, Love Paul E

Abstract excerpt

Mice homozygous for a single tyrosine mutation in LAT (linker for activation of T cells) exhibited an early block in T cell maturation but later developed a polyclonal lymphoproliferative disorder and signs of autoimmune disease. T cell antigen receptor (TCR)-induced activation of phospholipase C-gamma1 (PLC-gamma1) and of nuclear factor of activated T cells, calcium influx, interleukin-2 production, and cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Antinuclear
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD5 Antigens

Share to Interleukin-2

Share to Lymphoproliferative Disorders

Share to Phospholipase C gamma

Share to Thymus Gland

Share to Type C Phospholipases

Source

Identifiers

PMID: 12065840
DOI: 10.1126/science.1069066

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A LAT mutation that inhibits T cell development yet induces lymphoproliferation.PMID 12065840Read ↗

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.Semantic proximity Read ↗

LAT regulates gammadelta T cell homeostasis and differentiation.Semantic proximity Read ↗

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.Semantic proximity Read ↗

Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.Semantic proximity Read ↗

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.Semantic proximity Read ↗

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.Semantic proximity Read ↗

LAT polices T cell activation.Semantic proximity Read ↗

Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.