Article
Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.
The Journal of experimental medicine - 16 Jul 2001
Sommers C L, Menon R K, Grinberg A, Zhang W, Samelson L E, Love P E
Abstract excerpt
The integral membrane adapter protein linker for activation of T cells (LAT) performs a critical function in T cell antigen receptor (TCR) signal transduction by coupling the TCR to downstream signaling pathways. After TCR engagement, LAT is tyrosine phosphorylated by ZAP-70 creating docking sites for multiple src homology 2-containing effector proteins. In the Jurkat T cell line, the distal four tyrosines of LAT...
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