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Article

The role of prolines and glycine in the transmembrane domain of LAT.

The FEBS journal - 1 Jul 2021

Glatzová Daniela, Mavila Harsha, Saija Maria Chiara, Chum Tomáš, Cwiklik Lukasz, Brdička Tomáš, Cebecauer Marek

Abstract excerpt

Linker for activation in T cells (LAT) is a critical regulator of T-cell development and function. It organises signalling events at the plasma membrane. However, the mechanism, which controls LAT localisation at the plasma membrane, is not fully understood. Here, we studied the impact of helix-breaking amino acids, two prolines and one glycine, in the transmembrane segment on localisation and function of LAT....

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Identifiers

PMID: 33458942
DOI: 10.1111/febs.15713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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