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Article

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.

International immunology - 1 Jun 1999

Zhang W, Irvin B J, Trible R P, Abraham R T, Samelson L E

Abstract excerpt

The adaptor molecule LAT (linker for activation of T cells) is a palmitoylated integral membrane protein that localizes to the glycolipid-enriched microdomains in the plasma membrane. Upon TCR engagement, LAT becomes phosphorylated on multiple tyrosine residues and then binds several critical signaling molecules. Here, we describe the generation and characterization of a LAT-deficient cell line. Using this cell...

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Share to Antigens, Differentiation, T-Lymphocyte
Share to Calcium-Calmodulin-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Jurkat Cells

Share to Palmitic Acid

Share to Phospholipase C gamma

Share to Proto-Oncogene Proteins c-vav

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Share to Type C Phospholipases

Source

Identifiers

PMID: 10360968
DOI: 10.1093/intimm/11.6.943

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.PMID 10360968Read ↗

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.Semantic proximity Read ↗

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.Semantic proximity Read ↗

Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.Semantic proximity Read ↗

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.Semantic proximity Read ↗

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.Semantic proximity Read ↗

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.Semantic proximity Read ↗

Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.Semantic proximity Read ↗

The adapter proteins LAT and SLP-76 are required for T-cell activation.Semantic proximity Read ↗

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

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