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Article

Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.

Novartis Foundation symposium - 1 Jan 2007

Malissen Bernard, Wang Ying, Mingueneau Michael, Malissen Marie

Abstract excerpt

LAT (linker for activation of T cells) is an integral membrane adaptor protein that constitutes in T cells a major substrate of the ZAP-70 protein tyrosine kinase. LAT coordinates the assembly of a multiprotein signalling complex through phosphotyrosine-based motifs present within its intracytoplasmic segment. The resulting 'LAT signalosome' links the TCR to the main intracellular signalling pathways that...

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Source

Identifiers

PMID: 17534068
DOI: 10.1002/9780470062128.ch9

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.PMID 17534068Read ↗

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A LAT mutation that inhibits T cell development yet induces lymphoproliferation.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

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Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation.Semantic proximity Read ↗

Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways.Semantic proximity Read ↗

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.Semantic proximity Read ↗

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LAT encodes T cell activation pathway balanceSemantic proximity Read ↗

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