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Article

Interaction of propofol with voltage-gated human Kv1.5 channel through specific amino acids within the pore region.

European journal of pharmacology - 5 Oct 2015

Kojima Akiko, Ito Yuki, Ding Wei-Guang, Kitagawa Hirotoshi, Matsuura Hiroshi

Abstract excerpt

The intravenous anesthetic propofol affects the function of a diversity of ligand-gated and voltage-gated ion channels. However, there is little information as to whether propofol directly interacts with voltage-gated ion channel proteins to modulate their functions. The Kv1.5 channel is activated by membrane depolarization during action potentials and contributes to atrial repolarization in the human heart. This...

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Identifiers

PMID: 26256861
DOI: 10.1016/j.ejphar.2015.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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