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Article

Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.

European journal of pharmacology - 15 Nov 2016

Han Sheng-Na, Jing Ying, Yang Lin-Lin, Zhang Zhao, Zhang Li-Rong

Abstract excerpt

QT interval prolongation, a potential risk for arrhythmias, may result from gene polymorphisms relevant to cardiomyocyte repolarization. Another noted cause of QT interval prolongation is the administration of chemical compounds such as anesthetics, which may affect a specific type of cardiac K+ channel encoded by the human ether-a-go-go-related gene (hERG). hERG K+ current was recorded using whole-cell patch...

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Identifiers

PMID: 27575519
DOI: 10.1016/j.ejphar.2016.08.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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