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Article

Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.

The Journal of physiology - 1 Jun 2007

McNulty Megan M, Edgerton Gabrielle B, Shah Ravi D, Hanck Dorothy A, Fozzard Harry A, Lipkind Gregory M

Abstract excerpt

Our homology molecular model of the open/inactivated state of the Na(+) channel pore predicts, based on extensive mutagenesis data, that the local anaesthetic lidocaine docks eccentrically below the selectivity filter, such that physical occlusion is incomplete. Electrostatic field calculations suggest that the drug's positively charged amine produces an electrostatic barrier to permeation. To test the effect of...

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Identifiers

PMID: 17363383
DOI: 10.1113/jphysiol.2007.130161
PMCID: PMC2075178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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