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Article

Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.

Molecular pharmacology - 1 Oct 2014

Poulin Hugo, Bruhova Iva, Timour Quadiri, Theriault Olivier, Beaulieu Jean-Martin, Frassati Dominique, Chahine Mohamed

Abstract excerpt

The voltage-gated Nav1.5 channel is essential for the propagation of action potentials in the heart. Malfunctions of this channel are known to cause hereditary diseases. It is a prime target for class 1 antiarrhythmic drugs and a number of antidepressants. Our study investigated the Nav1.5 blocking properties of fluoxetine, a selective serotonin reuptake inhibitor. Nav1.5 channels were expressed in HEK-293 cells,...

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Source

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Identifiers

PMID: 25028482
DOI: 10.1124/mol.114.093104
PMCID: PMC4164981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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