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Article

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.

The Journal of general physiology - 1 Sept 2013

Perry Matthew D, Wong Sophia, Ng Chai Ann, Vandenberg Jamie I

Abstract excerpt

Kv11.1 channels are critical for the maintenance of a normal heart rhythm. The flow of potassium ions through these channels is controlled by two voltage-regulated gates, termed "activation" and "inactivation," located at opposite ends of the pore. Crucially in Kv11.1 channels, inactivation gating occurs much more rapidly, and over a distinct range of voltages, compared with activation gating. Although it is...

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Identifiers

PMID: 23980196
DOI: 10.1085/jgp.201310975
PMCID: PMC3753607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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