Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel.

British journal of pharmacology - 1 Jan 2009

Wu J, Ding W-G, Matsuura H, Tsuji K, Zang W-J, Horie M

Abstract excerpt

BACKGROUND AND PURPOSE: Kv1.5 channels conduct the ultra-rapid delayed rectifier potassium current (I(Kur)), and in humans, Kv1.5 channels are highly expressed in cardiac atria but are scarce in ventricles. Pharmacological blockade of human Kv1.5 (hKv1.5) has been regarded as effective for prevention and treatment of re-entry-based atrial tachyarrhythmias. Here we examined blockade of hKv1.5 channels by LY294002,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androstadienes
Share to Chromones
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Morpholines

Share to Patch-Clamp Techniques

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Wortmannin

Source

Open in PubMed Open full text

Identifiers

PMID: 19154427
DOI: 10.1111/j.1476-5381.2008.00017.x
PMCID: PMC2697827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel.PMID 19154427Read ↗

Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain.Semantic proximity Read ↗

Putative binding sites for arachidonic acid on the human cardiac Kv 1.5 channel.Semantic proximity Read ↗

Interaction of propofol with voltage-gated human Kv1.5 channel through specific amino acids within the pore region.Semantic proximity Read ↗

Electrophysiological characterization of three non-synonymous single nucleotide polymorphisms (R87Q, A251T, and P307S) found in hKv1.5.Semantic proximity Read ↗

Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition.Semantic proximity Read ↗

Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase.Semantic proximity Read ↗

Comparison of the effects of antiarrhythmic drugs flecainide and verapamil on fKv1.4ΔN channel currents in Xenopus oocytes.Semantic proximity Read ↗

Quercetin activates human Kv1.5 channels by a residue I502 in the S6 segment.Semantic proximity Read ↗

Characterisation of Kv4.3 in HEK293 cells: comparison with the rat ventricular transient outward potassium currentSemantic proximity Read ↗

A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca2+-activated K+ (BKCa) channels.Semantic proximity Read ↗

Constitutive inactivation of the hKv1.5 mutant channel, H463G, in K+-free solutions at physiological pH.Semantic proximity Read ↗

The Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin Inhibits Long QT 3 Late Sodium Currents in a Mutation Specific MannerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.