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Article

Interactions of Propofol With Human Voltage-gated Kv1.5 Channel Determined by Docking Simulation and Mutagenesis Analyses.

Journal of cardiovascular pharmacology - 1 Jan 2018

Kojima Akiko, Fukushima Yutaka, Ito Yuki, Ding Wei-Guang, Ueda Rika, Seto Tomoyoshi, Kitagawa Hirotoshi, Matsuura Hiroshi

Abstract excerpt

Propofol blocks the voltage-gated human Kv1.5 (hKv1.5) channel by preferentially affecting in its open state. A previous mutational study suggested that several amino acids within the pore region of the hKv1.5 channel are involved in mediating the blocking action of propofol. The present investigation was undertaken to elucidate the predicted binding modes of propofol within the pore cavity of the open-state...

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Identifiers

PMID: 29283926
DOI: 10.1097/FJC.0000000000000538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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