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Article

Putative binding sites for arachidonic acid on the human cardiac Kv 1.5 channel.

British journal of pharmacology - 1 Nov 2015

Bai Jia-Yu, Ding Wei-Guang, Kojima Akiko, Seto Tomoyoshi, Matsuura Hiroshi

Abstract excerpt

BACKGROUND AND PURPOSE: In human heart, the Kv 1.5 channel contributes to repolarization of atrial action potentials. This study examined the electrophysiological and molecular mechanisms underlying arachidonic acid (AA)-induced inhibition of the human Kv 1.5 (hKv 1.5) channel. EXPERIMENTAL APPROACH: Site-directed mutagenesis was conducted to mutate amino acids that reside within the pore domain of the hKv 1.5...

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Identifiers

PMID: 26292661
DOI: 10.1111/bph.13314
PMCID: PMC5341216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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