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Article

Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain.

Journal of molecular and cellular cardiology - 1 Dec 2011

Wu Hui-Jun, Wu Wei, Sun Hai-Ying, Qin Guo-Wei, Wang Hong-Bing, Wang Panwen, Yalamanchili Hari Krishna, Wang Junwen, Tse Hung-Fat, Lau Chu-Pak, Vanhoutte Paul M, Li Gui-Rong

Abstract excerpt

We have demonstrated that the natural flavone acacetin selectively inhibits ultra-rapid delayed rectifier potassium current (I(Kur)) in human atria. However, molecular determinants of this ion channel blocker are unknown. The present study was designed to investigate the molecular determinants underlying the ability of acacetin to block hKv1.5 channels (coding I(Kur)) in human atrial myocytes using the whole-cell...

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Identifiers

PMID: 21906601
DOI: 10.1016/j.yjmcc.2011.08.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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